SAGE II (Study of African Americans, Asthma, Genes Environments)

SAGE II (Study of African Americans, Asthma, Genes Environments) SAGE II is a NIH funded, case control cohort of 1,227 African American youths (8 21 years) recruited at the University of California, San Francisco. The dataset combines high resolution genomic data (GWAS and whole genome sequencing), detailed phenotypes (physician diagnosed asthma status, bronchodilator response, spirometry, body mass index), and a rich set of environmental measures (local air quality, second hand smoke exposure, socioeconomic status, experiences of discrimination, diet, and medication use). The study was designed and coordinated by the Asthma Collaboratory at UCSF, with principal investigators L. Burchard and M. White and major support from the NHLBI, the Sandler Family Foundation, and the TOPMed program. Its primary purpose is to uncover gene environment interactions that drive asthma susceptibility, severity, and drug response in African American children populations historically under represented in respiratory genetics research. Key features that set SAGE II apart include: (1) the largest gene environment investigation of asthma in African American youth; (2) comprehensive ancestry admixture estimates enabling fine scale genetic analyses; (3) paired pharmacogenomic data on bronchodilator responsiveness; and (4) publicly available raw and processed data through dbGaP/TOPMed, making it a valuable resource for studies of health disparities, precision medicine, and environmental genomics.